Wednesday, February 06, 2008

One New Step and the Completion of Another

Meet my Handsome blue-eyed red headed grandson. He heralded the start of his new life last week after serveral false starts. Because of treatments it was 3 days later that we got to meet him. This was the second grandchild delivery I missed, not a good trend.

In the mean time, we have finished the first radiation treatments, with a big question mark as to if there will be more. Ned is distressed that their only plan had been to reduce the size of the cancer not remove or destroy the offending cancer. It was supposed to help reduce his buttock pain but that has not happened yet, and we are done. Sigh.

We have been approved for have chemotherapy. I say approved because we had to apply for treatment financial aid as the cost of one drug alone is at the $140,000 amount.

He will be receiving AVASTIN®, in combination with intravenous 5-fluorouracil- (this interferes with metabolic machinery in synthesis of nucleic acids) based chemotherapy and Eloxatin (oxaliplatin)[ which first mechanism an alkylating agent attaches alkyl groups to DNA bases. This alteration results in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases. Second mechanism by which alkylating agents cause DNA damage is the formation of cross-bridges, bonds between atoms in the DNA. In this process, two bases are linked together by an alkylating agent that has two DNA binding sites. Cross-linking prevents DNA from being separated for synthesis or transcription. The third mechanism of action of alkylating agents causes the mispairing of the nucleotides leading to mutations.

If anyone can explain the alkylated agent in layman terms, I would appreciate it.

I am now really pushing to have the correct alkalizing diet in place since that is the one that has the best effect on colon cancers, and lung cancers.

It was refreshing to visit with the pain management doctor. She knew kenesiology, understood aroma therapy and is certified in accupuncture. I have felt more comfortable with her than anyother doctor. She also did problem solving not just application of a medication for a specfic complaint and also did great teaching using a skeleton and diagrams. Best I have seen so far.

Tomorrow is another two tests, I have to pick up the pickup and trailer to pick up citrus for the spring. I will have to leave my hero alone, but the only place I have to take the test is back at home. The librarians down here have said they don't proctor.

A diller a dollar a 10 o'clock scholar. I must be off to bed.

Nite all

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